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KMID : 0928320050050010045
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Korean Journal of Health Promotion and Disease Prevention
2005 Volume.5 No. 1 p.45 ~ p.53
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Relationships between diet, hypermethylation of pS2 and mutations of the p53 and Ki-ra genes ingastric cancer patients
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Lee Jung-Yup
Youn Sei-Jin
Kang Jong-Won
Yun Hyo-Yung
Song Young-Jin
Park Joo-Seung
Hyun Tai-Sun
Kim Yong-Dae
Kim Heon
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Abstract
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Backgrounds:The aim of this study was to investigate effects of dietary factors on hypermethylation in the promoter of pS2 gene and on mutations in p53 and Ki-ras genes in relationship with hypermethylation of the pS2 gene promoter in gastric cancers.
Methods: One hundred and ten patients with stomach cancer and 220 age- and sex-matched controls were
enrolled in this study. Information on the level of exposure to dietary factors was obtained by direct interview. The hypermethylation of the pS2 gene promoter region and mutations in the p53 and Ki-ras genes were investigated with DNA from gastric cancer tissue.
Results: In gastric cancer patients, diet high in steamed rice and chicken such as roast chicken, boiled chicken,
chicken soup, and that low in rice cake, lard and ice cream also increased the frequency of hypermethylation of pS2 gene promoter. However, hypermethylation of the pS2 gene promoter did not influence on the mutations of p53 and Ki-ras genes.
Conslusions: The hypermethylation of pS2 promoter region would play an important role in the gastric carcinogenesis, but would not induce the genetic mutation of p53 and Ki-ras gene in gastric cancer patients. None of the dietary factors was statistically associated with hypermethylation of pS2 promoter region and genetic mutation of p53 and Ki-ras genes at the same time. It is suggested that hypermethylation of pS2 gene promoter, and genetic mutations of p53 and Ki-ras genes do not share a common pathway in developing gastric cancer in Koreans.
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KEYWORD
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Gastric cancer, Environmental carcinogens, Hypermethylation, pS2, p53, Ki-ras
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